Moore was born in Baltimore, Maryland and in his starting adult years, he attended Baltimore City College. After dropping out of high school, Moore found success as a radio host and then moved on to the television industry. He hosted The Garry Moore Show, and the game shows I've Got a Secret and To Tell the Truth. He became known for his bow ties and his crew cut, though he refrained from both fashions later in his career. Garry was also a panelist on the original Password.
After being diagnosed with throat cancer in 1976, Moore retired from the television industry, making a few rare television appearances. One of his last was on Sally Jessy Raphael. He spent the last years of his life in South Carolina and at his summer home in Maine. He died on November 28, 1993.